Thyroid Hormone Receptor Alpha (THRA) Antibody

Product specifications

Primary Antibodies

Target: Thyroid Hormone Receptor Alpha (THRA)
Immunogen: abx615231 - Internal region: C-KEEMIRSLQQRP

Goat

Human

Concentration: 0.5 mg/ml

P-ELISA: 1/32000, WB: 0.5 - 1 µg/ml, IHC-P: 3.75 µg/ml. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

200 µl

Liquid

P-ELISA, WB, IHC

Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

7067, 21833, 81812

NP_955366.1, NP_003241.2

AR7,EAR7,ERBA,ERBA1,NR1A1,THRA1,THRA2,c-erbA,ERB-T-1,Tralpha,THRalpha,TRalpha1,TRalpha2,c-ERBA-1,THRalpha1,THRalpha2,Nuclear receptor subfamily 1 group A member 1,V-erbA-related protein 7

Antibody anti-THRA

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

Thyroid hormone receptor alpha (THRA) is a nuclear receptor that mediates the effects of thyroid hormones (T3 and T4) by regulating gene expression THRA exists in multiple isoforms, which are generated through alternative splicing and have tissue-specific functions The receptor plays a crucial role in the development, growth, and metabolism of various tissues, including the brain, heart, and muscles THRA regulates cellular processes such as metabolism, thermogenesis, and lipid metabolism by influencing the transcription of target genes involved in these pathways The receptor also has a vital role in the development of the nervous system, particularly during fetal and postnatal development Mutations in THRA can lead to various thyroid-related disorders, including resistance to thyroid hormone (RTH), where tissues become less responsive to thyroid hormones, resulting in elevated thyroid hormone levels and metabolic disturbances Additionally, THRA dysregulation has been implicated in certain cancers, where altered thyroid hormone signaling can contribute to tumor growth and progression

Related Products

Thyroid Hormone Receptor Alpha (THRA) Peptide

Thyroid Hormone Receptor Alpha (THRA) Peptide is a synthetic peptide. This peptide is used in the production of

Ver Producto