Thyroid Hormone Receptor Alpha (THRA) Antibody
221€ (50 µg)
221€ (50 µg)
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935106861
info@markelab.com
name
Thyroid Hormone Receptor Alpha (THRA) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx328428
tested applications
ELISA, WB, IHC
Descripción del producto
THRA Antibody is a Rabbit Polyclonal against THRA.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | AR7,EAR7,ERBA,ERBA1,NR1A1,THRA1,THRA2,c-erbA,ERB-T-1,Tralpha,THRalpha,TRalpha1,TRalpha2,c-ERBA-1,THRalpha1,THRalpha2,Nuclear receptor subfamily 1 group A member 1,V-erbA-related protein 7 |
| Availability | Shipped within 5-10 working days. |
| Background | Antibody anti-THRA |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Dry Ice | No |
| Form | Liquid |
| Gene ID | 7067 |
| Host | Rabbit |
| Immunogen Target | Thyroid Hormone Receptor Alpha (THRA) |
| Isotype | IgG |
| Name | Thyroid Hormone Receptor Alpha (THRA) Antibody |
| Price | 221 |
| Provider | Abbexa |
| Purification | Purified by affinity chromatography. |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx328428 |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Tested Applications | ELISA, WB, IHC |
| UniProt ID | P10827 |
Descripcion del producto en español
Background en español
Thyroid hormone receptor alpha (THRA) is a nuclear receptor that mediates the effects of thyroid hormones (T3 and T4) by regulating gene expression THRA exists in multiple isoforms, which are generated through alternative splicing and have tissue-specific functions The receptor plays a crucial role in the development, growth, and metabolism of various tissues, including the brain, heart, and muscles THRA regulates cellular processes such as metabolism, thermogenesis, and lipid metabolism by influencing the transcription of target genes involved in these pathways The receptor also has a vital role in the development of the nervous system, particularly during fetal and postnatal development Mutations in THRA can lead to various thyroid-related disorders, including resistance to thyroid hormone (RTH), where tissues become less responsive to thyroid hormones, resulting in elevated thyroid hormone levels and metabolic disturbances Additionally, THRA dysregulation has been implicated in certain cancers, where altered thyroid hormone signaling can contribute to tumor growth and progression
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Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.
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