Thy-1 Membrane Glycoprotein (THY1) Antibody

Descripción

THY1 Antibody is a Rabbit Polyclonal antibody against THY1. THY1 is a GPI-anchored, developmentally regulated protein involved in various signaling cascades that mediate neurite outgrowth, T cell activation, tumor suppression, apoptosis, and fibrosisIt is highly expressed on the surface of adult neurons and is thought to play a role in modulating adhesive and migRatory events, such as neurite extensionDecreased THY1 expression is associated with the development of epithelial ovarian cancer, revealing its role as a putative tumor suppressor gene of human ovarian cancerTHY1 knockout mice have impaired cutaneous immune responses and abnormal retinal developmentTHY1 is epigenetically regulated, or deregulated in some disease states, such as pulmonary fibrosisThe potentially reversible hypermethylation of the THY1 promoter offers the possibility of novel therapeutic options in this disease.