Thy-1 Membrane Glycoprotein (THY1) Antibody
468€ (100 µl)
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935106861
info@markelab.com
name
Thy-1 Membrane Glycoprotein (THY1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx117215
tested applications
ELISA, WB, IHC
Description
THY1 Antibody is a Rabbit Polyclonal antibody against THY1. THY1 is a GPI-anchored, developmentally regulated protein involved in various signaling cascades that mediate neurite outgrowth, T cell activation, tumor suppression, apoptosis, and fibrosisIt is highly expressed on the surface of adult neurons and is thought to play a role in modulating adhesive and migRatory events, such as neurite extensionDecreased THY1 expression is associated with the development of epithelial ovarian cancer, revealing its role as a putative tumor suppressor gene of human ovarian cancerTHY1 knockout mice have impaired cutaneous immune responses and abnormal retinal developmentTHY1 is epigenetically regulated, or deregulated in some disease states, such as pulmonary fibrosisThe potentially reversible hypermethylation of the THY1 promoter offers the possibility of novel therapeutic options in this disease.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Thy-1 Membrane Glycoprotein (THY1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P04216 |
| Gene ID | 7070 |
| Alias | Thy-1 membrane glycoprotein,CD90,CDw90,Thy-1 antigen |
| Background | Antibody anti-THY1 |
| Status | RUO |
Descripción
THY1, also known as CD90, is a glycoprotein encoded by the THY1 gene in humans. Initially identified as a marker for T cells, THY1 is now known to have broader expression across a variety of cell types, including neurons, fibroblasts, endothelial cells, and certain stem cells. THY1 plays a significant role in cell-cell and cell-matrix interactions and has been extensively studied in relation to immune regulation, inflammation, fibrosis, tissue regeneration, and neurobiology. Due to its multifunctional role, THY1 is a notable target in therapeutic research, especially in fields related to fibrosis and regenerative medicine.
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