Thromboxane A2 Receptor Isoform Beta (TBXA2R) Antibody
416€ (200 µl)
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name
Thromboxane A2 Receptor Isoform Beta (TBXA2R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433371
tested applications
P-ELISA, WB
Description
Thromboxane A2 receptor Isoform beta (TBXA2R) Antibody is a Goat Polyclonal antibody against Thromboxane A2 receptor Isoform beta (TBXA2R).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Thromboxane A2 Receptor Isoform Beta (TBXA2R) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/128000, WB: 0.03-0.1 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 6915 |
| NCBI Accession | NP_963998.2 |
| Alias | TBXA2R,prostanoid TP receptor,TXA2-R,BDPLT13 |
| Background | Antibody anti-TBXA2R |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
The thromboxane A2 receptor (TBXA2R), also known as TP, is a G protein-coupled receptor activated by thromboxane A2 (TXA2), a lipid mediator that promotes vasoconstriction, platelet aggregation, and inflammation. TBXA2R primarily couples to Gq and G12/13 proteins, activating phospholipase C (PLC), increasing intracellular calcium levels, and triggering Rho-mediated pathways that regulate smooth muscle contraction and platelet activation. TBXA2R is highly expressed in platelets, vascular smooth muscle cells, and immune cells, where it plays a pivotal role in hemostasis, thrombosis, and vascular tone. Dysregulation of TBXA2R signaling contributes to thrombotic disorders, hypertension, and atherosclerosis. TBXA2R antagonists, such as terutroban, are being developed as antithrombotic agents to reduce platelet aggregation and treat cardiovascular diseases. Targeting TBXA2R provides therapeutic potential for managing thrombosis, pulmonary hypertension, and inflammatory vascular diseases by modulating TXA2-mediated effects.
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