THO Complex Subunit 4 / THOC4 (ALYREF) Antibody

Background

ALYREF, also known as Aly/REF export factor, is a protein involved in the process of mRNA export from the nucleus to the cytoplasm in eukaryotic cells. mRNA (messenger RNA) carries genetic information from the DNA in the cell nucleus to the cytoplasm, where it serves as a template for protein synthesis. ALYREF is a member of the Aly/REF family of proteins and is essential for the export of mature mRNA molecules from the nucleus. It functions by interacting with other proteins and RNA molecules to facilitate the assembly of messenger ribonucleoprotein (mRNP) complexes, which are then transported through nuclear pores to the cytoplasm.The role of ALYREF in mRNA export is particularly important for the regulation of gene expression and the proper functioning of cells. Dysregulation of mRNA export can lead to various cellular abnormalities and diseases, including cancer and developmental disorders. ALYREF interacts with other proteins involved in mRNA export, such as the TREX (TRanscription-EXport) complex, which helps recruit ALYREF to mRNA molecules and facilitates their export. Additionally, ALYREF interacts with specific RNA sequences and structures, such as the mRNA export element (REF) found in certain viral RNAs, to promote their export from the nucleus.