CD63 Antigen (CD63) Antibody
357.5€ (100 µg)
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Name
CD63 Antigen (CD63) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx340098
Tested Applications
ELISA, WB
Description
CD63 Antibody is a Rabbit Polyclonal against CD63.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: CD63 Antigen (CD63) Immunogen: A peptide corresponding to middle region of human CD63 protein. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 43 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08962 |
| Gene ID | 967 |
| NCBI Accession | NM_001780.5 |
| OMIM | 155740 |
| Alias | AD1,MLA1,ME491,HOP-26,OMA81H,Pltgp40,TSPAN30,Granulophysin,Lysosomal-associated membrane protein 3,Melanoma-associated antigen ME491 |
| Background | Antibody anti-CD63 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD63 molecule (CD63) is a transmembrane protein that belongs to the tetraspanin family, widely expressed in a variety of cell types and tissues. It plays a significant role in multiple biological processes, including immune response, cell adhesion, and intracellular trafficking. CD63 is prominently localized on late endosomes, lysosomes, and the plasma membrane, where it participates in the regulation of membrane fusion and vesicle trafficking. One of its most recognized roles is as a marker of exosomes, small extracellular vesicles released by cells, which makes it pivotal in cell-to-cell communication and a key target in exosome research for diagnostics and therapeutics. CD63 also interacts with integrins and other tetraspanins, facilitating cell adhesion and migration, processes that are critical in immune surveillance and tissue repair. It is involved in the activation of basophils and mast cells, contributing to allergic responses. Additionally, aberrations in CD63 expression or function are linked to pathological conditions, such as cancer metastasis, where it influences tumor cell invasiveness and immune evasion. Its expression has also been implicated in autoimmune diseases and infections. Given its multifunctional role and association with several diseases, CD63 continues to be an important molecule in immunological and biomedical research.
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