CD63 Antigen (CD63) Antibody
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Description
CD63 Antibody is a Rabbit Polyclonal against CD63.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CD63 Antigen (CD63) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, WB: 1/200 - 1/1000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08962 |
| Gene ID | 967 |
| OMIM | 155740 |
| Alias | AD1,MLA1,ME491,HOP-26,OMA81H,Pltgp40,TSPAN30,Granulophysin,Lysosomal-associated membrane protein 3,Melanoma-associated antigen ME491 |
| Background | Antibody anti-CD63 |
| Status | RUO |
Descripción
CD63 molecule (CD63) is a transmembrane protein that belongs to the tetraspanin family, widely expressed in a variety of cell types and tissues. It plays a significant role in multiple biological processes, including immune response, cell adhesion, and intracellular trafficking. CD63 is prominently localized on late endosomes, lysosomes, and the plasma membrane, where it participates in the regulation of membrane fusion and vesicle trafficking. One of its most recognized roles is as a marker of exosomes, small extracellular vesicles released by cells, which makes it pivotal in cell-to-cell communication and a key target in exosome research for diagnostics and therapeutics. CD63 also interacts with integrins and other tetraspanins, facilitating cell adhesion and migration, processes that are critical in immune surveillance and tissue repair. It is involved in the activation of basophils and mast cells, contributing to allergic responses. Additionally, aberrations in CD63 expression or function are linked to pathological conditions, such as cancer metastasis, where it influences tumor cell invasiveness and immune evasion. Its expression has also been implicated in autoimmune diseases and infections. Given its multifunctional role and association with several diseases, CD63 continues to be an important molecule in immunological and biomedical research.
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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
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