Testin (TES) Antibody
169€ (20 µg)
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935106861
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name
Testin (TES) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx349512
tested applications
ELISA, WB, IHC, IF/ICC
Description
Testin (TES) Antibody is a Rabbit Polyclonal antibody for the detection of Human TES.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Testin (TES) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UGI8 |
| Alias | TESS,TESS-2 |
| Background | Antibody anti-TES |
| Status | RUO |
Descripción
TES is a tumor suppressor protein that belongs to the LIM domain-containing family, functioning in actin cytoskeletal organization, cell adhesion, and signaling regulation. TES interacts with focal adhesion proteins and actin-binding molecules to regulate cellular processes such as cell spreading, migration, and morphology. It acts as a scaffolding protein at focal adhesions, mediating interactions between the actin cytoskeleton and signaling molecules to maintain cell adhesion and structural integrity. TES is also involved in transcriptional regulation by interacting with nuclear proteins, including transcription factors, to control gene expression associated with cell growth and differentiation. Downregulation of TES is commonly observed in cancers, where its loss disrupts cytoskeletal organization and promotes tumor progression, metastasis, and reduced cell adhesion. Knockdown studies reveal increased cell motility, reduced cell adhesion, and enhanced invasive capacity, emphasizing TES’s critical role in maintaining cytoskeletal stability, suppressing tumor growth, and regulating cellular architecture.
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