Telomeric Repeat Binding Factor 2 (TERF2) Antibody
819€ (1 ml)
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Name
Telomeric Repeat Binding Factor 2 (TERF2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx174737
Tested Applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Telomeric Repeat Binding Factor 2 (TERF2) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | TERF2, TRBF2, TRF2,TTAGGG repeat-binding factor 2 |
| Background | Antibody anti-TERF2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TERF2, or TRF2, is a core component of the shelterin complex that binds double-stranded telomeric DNA to protect chromosome ends from degradation, DNA damage signaling, and end-to-end fusions. TERF2 functions by remodeling telomeric DNA into t-loop structures that mask chromosome termini and prevent activation of the ATM-mediated DNA damage response pathway. It also regulates telomere stability during replication and ensures proper telomere capping in both dividing and quiescent cells. TERF2 is essential for telomere maintenance, cellular longevity, and genomic stability, particularly in rapidly proliferating cells like stem cells and cancer cells. Dysregulation of TERF2 is implicated in diseases such as cancer, where its overexpression allows cells to bypass senescence, and in aging-related disorders, where telomere shortening accelerates cellular decline. Knockout studies show telomere deprotection, activation of DNA damage checkpoints, and increased chromosome end fusions, emphasizing TERF2's critical role in telomere capping, genomic stability, and cell fate regulation.
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