Tachykinin Receptor 2 (TACR2) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Tachykinin Receptor 2 (TACR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx211186
tested applications
ELISA, WB, IHC
Description
TACR2 Antibody is a Rabbit Polyclonal against TACR2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tachykinin Receptor 2 (TACR2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, WB: 1/500 - 1/2000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21452 |
| Gene ID | 6865 |
| Alias | TACR2,Neurokinin B receptor,NKNAR,SKR,TAC2R,neurokinin A receptor,NK-2 receptor,P-E receptor,Substance K receptor,NK2R |
| Background | Antibody anti-TACR2 |
| Status | RUO |
Descripción
TACR2, also known as NK2R, is another member of the tachykinin receptor family, activated by neurokinin B (NKB) and substance P. Like TACR1, TACR2 primarily couples to Gq proteins, which activate phospholipase C (PLC), generating inositol triphosphate (IP3) and increasing intracellular calcium levels. TACR2 is widely expressed in the smooth muscle, particularly in the respiratory and gastrointestinal systems, where it regulates smooth muscle contraction. In the CNS, TACR2 plays a key role in regulating neurogenic inflammation and modulating pain, as well as contributing to the regulation of reproductive function. Dysregulation of TACR2 signaling has been linked to conditions such as asthma, chronic pain syndromes, and reproductive disorders. Selective TACR2 antagonists are being developed to treat asthma, IBS, and other conditions where neurokinin B-mediated effects contribute to disease pathology.
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