Tachykinin Receptor 2 (TACR2) Antibody
741€ (1 ml)
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Name
Tachykinin Receptor 2 (TACR2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx174708
Tested Applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Tachykinin Receptor 2 (TACR2) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | TACR2,Neurokinin B receptor,NKNAR,SKR,TAC2R,neurokinin A receptor,NK-2 receptor,P-E receptor,Substance K receptor,NK2R |
| Background | Antibody anti-TACR2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TACR2, also known as NK2R, is another member of the tachykinin receptor family, activated by neurokinin B (NKB) and substance P. Like TACR1, TACR2 primarily couples to Gq proteins, which activate phospholipase C (PLC), generating inositol triphosphate (IP3) and increasing intracellular calcium levels. TACR2 is widely expressed in the smooth muscle, particularly in the respiratory and gastrointestinal systems, where it regulates smooth muscle contraction. In the CNS, TACR2 plays a key role in regulating neurogenic inflammation and modulating pain, as well as contributing to the regulation of reproductive function. Dysregulation of TACR2 signaling has been linked to conditions such as asthma, chronic pain syndromes, and reproductive disorders. Selective TACR2 antagonists are being developed to treat asthma, IBS, and other conditions where neurokinin B-mediated effects contribute to disease pathology.
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