T-lymphocyte activation antigen CD80 / B7-1 (CD80) Antibody

Este producto es parte de CD80 molecule
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383.5€ (100 µl)

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935106861
info@markelab.com
name
T-lymphocyte activation antigen CD80 / B7-1 (CD80) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015727
tested applications
ELISA, IHC, IF/ICC

Description

The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival.It is also known as B7.1.Its principal mode of action is by binding to CD28.Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells.CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells.Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells.Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions.In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation."When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans.Osteoclasts cause minerals to be released from the bone, so that calcium is taken into the bloodstream to be used for other functions of the body.Osteoclast differentiation is inhibited by osteoprotegerin; Estrogen stimulates osteoprotegerin production.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
T-lymphocyte activation antigen CD80 / B7-1 (CD80)
Host
Mouse
Reactivity
Human
Recommended Dilution
ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Purification
Unpurified ascites.
Size 1
100 µl
Form
Liquid
Tested Applications
ELISA, IHC, IF/ICC
Buffer
Ascitic fluid containing 0.03% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Gene ID
941, 12519, 100009377
Alias
B7,BB1,B7-1,B7.1,LAB7,CD28LG,CD28LG1,Activation B7-1 antigen,CTLA-4 counter-receptor B7.1,T-lymphocyte activation antigen CD80
Background
Antibody anti-CD80
Status
RUO
Note
Concentration: Not determined. -

Descripción

CD80, also known as B7-1, is a protein encoded by the CD80 gene in humans. It is an essential costimulatory molecule expressed on the surface of antigen-presenting cells (APCs) such as dendritic cells, B cells, and macrophages. CD80 plays a critical role in the regulation of immune responses by providing the necessary second signal for T cell activation and survival. This molecule interacts with CD28 and CTLA-4 receptors on T cells, mediating various immune responses. The discovery and understanding of CD80 have significant implications for immunology, particularly in the context of autoimmune diseases, transplant rejection, and cancer immunotherapy.

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