T-Cell Surface Protein Tactile (CD96) Antibody
273€ (200 µl)
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935106861
info@markelab.com
name
T-Cell Surface Protein Tactile (CD96) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432483
tested applications
P-ELISA
Description
CD96 Antibody is a Goat Polyclonal antibody against CD96.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | T-Cell Surface Protein Tactile (CD96) |
| Host | Goat |
| Recommended Dilution | P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 10225 |
| NCBI Accession | NP_937839.1, NP_005807.1 |
| Alias | T-cell surface protein tactile,TACTILE,T cell-activated increased late expression protein |
| Background | Antibody anti-CD96 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
The CD96 molecule, also known as TACTILE (T-cell-activated increased late expression), is a transmembrane glycoprotein predominantly expressed on the surface of NK cells and certain subsets of T cells. This protein plays a crucial role in the regulation of immune responses, specifically within the innate immune system, by modulating the activity of NK cells. CD96 is part of the immunoglobulin superfamily and is closely related to other checkpoint receptors such as TIGIT (T cell immunoreceptor with Ig and ITIM domains) and CD226. It has structural and functional similarities with these receptors, which are involved in immune cell interactions and responses to cellular stress signals, infection, and malignant transformations. CD96 binds to the ligand CD155, also known as poliovirus receptor (PVR), which is broadly expressed on various cell types, including endothelial cells and tumor cells. Through its interaction with CD155, CD96 modulates NK cell cytotoxicity and plays a part in controlling the inflammatory response and immunological synapse formation between NK cells and target cells. By balancing activating and inhibitory signals, CD96 ensures immune homeostasis, minimizing the risk of autoimmune responses while enabling effective pathogen and tumor surveillance.
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