T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody (Biotin)

Product specifications

Primary Antibodies

T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A)

Rat

Mouse

Monoclonal

Biotin

IgG2a

25 µg

100 µg

FCM

PBS with 0.05% Proclin300, 1% BSA.

Shipped within 5-15 working days.

Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. Do not freeze.

No

P01731

12525

CD8,p32,Leu2,IMD116,CD8alpha,MAL,T-lymphocyte differentiation antigen T8/Leu-2,T-cell surface glycoprotein CD8 alpha chain

Antibody anti-CD8A

RUO

Descripción

The CD8A gene encodes the alpha subunit of the CD8 glycoprotein, a key co-receptor expressed on the surface of cytotoxic T lymphocytes (CD8+ T cells). CD8A typically forms a heterodimer with CD8B or a homodimer (CD8αα). This protein plays a central role in T-cell activation and immune surveillance by interacting with MHC class I molecules on antigen-presenting cells. The interaction stabilizes the binding of the T-cell receptor (TCR) to antigenic peptides presented by MHC class I, facilitating signal transduction and T-cell-mediated cytotoxic responses. CD8A expression is essential for the development and maturation of CD8+ T cells in the thymus. It also participates in the immune response against viral infections, tumors, and intracellular pathogens. Mutations or dysregulation of CD8A can impair T-cell function and immune homeostasis.

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