T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody
221€ (0.1 mg)
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935106861
info@markelab.com
name
T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx140019
tested applications
IHC, IF/ICC, FCM, IP
Description
CD8a Antibody is a Rat Monoclonal against CD8a.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) |
| Host | Rat |
| Reactivity | Mouse |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a Kappa |
| Clone ID | T604 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein G affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | IHC, IF/ICC, FCM, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P01731 |
| Gene ID | 12525 |
| Alias | CD8,p32,Leu2,IMD116,CD8alpha,MAL,T-lymphocyte differentiation antigen T8/Leu-2,T-cell surface glycoprotein CD8 alpha chain |
| Background | Antibody anti-CD8A |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
The CD8A gene encodes the alpha subunit of the CD8 glycoprotein, a key co-receptor expressed on the surface of cytotoxic T lymphocytes (CD8+ T cells). CD8A typically forms a heterodimer with CD8B or a homodimer (CD8αα). This protein plays a central role in T-cell activation and immune surveillance by interacting with MHC class I molecules on antigen-presenting cells. The interaction stabilizes the binding of the T-cell receptor (TCR) to antigenic peptides presented by MHC class I, facilitating signal transduction and T-cell-mediated cytotoxic responses. CD8A expression is essential for the development and maturation of CD8+ T cells in the thymus. It also participates in the immune response against viral infections, tumors, and intracellular pathogens. Mutations or dysregulation of CD8A can impair T-cell function and immune homeostasis.
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