T-Cell Surface Glycoprotein CD3 Gamma Chain (CD3G) Antibody
442€ (200 µl)
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935106861
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name
T-Cell Surface Glycoprotein CD3 Gamma Chain (CD3G) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431152
tested applications
P-ELISA, WB
Description
CD3G Antibody is a Goat Polyclonal antibody against CD3G.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: T-Cell Surface Glycoprotein CD3 Gamma Chain (CD3G) Immunogen: abx617266 - Internal region: C-QDGVRQSRASDKQT |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 917, 12502, 300678 |
| NCBI Accession | NP_000064.1 |
| Alias | T3G,IMD17,CD3GAMMA,CD3-GAMMA,T-cell surface glycoprotein CD3 gamma chain,T-cell receptor T3 gamma chain |
| Background | Antibody anti-CD3G |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
CD3G, the gamma subunit of the T-cell receptor (TCR) complex, is a crucial component of the TCR-CD3 complex, which plays an essential role in T-cell activation, signal transduction, and immune responses. The TCR-CD3 complex is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). This recognition initiates signaling cascades that activate T cells, leading to immune responses such as T-cell proliferation, cytokine production, and differentiation into effector cells. The CD3 complex consists of multiple subunits, including CD3G (gamma), CD3E (epsilon), CD3D (delta), and CD3Z (zeta), which associate with the TCR α/β or γ/δ heterodimers to form the full TCR-CD3 complex. The CD3G gene is located on chromosome 11q23, adjacent to the CD3D gene. It encodes the CD3γ chain, a transmembrane protein that is integral to the structural stability and function of the TCR-CD3 complex. CD3G is expressed on the surface of all mature T lymphocytes and certain natural killer (NK) cells, where it contributes to immune surveillance, host defense against infections, and recognition of transformed cells (e.g., tumor cells).
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