T-cell Surface Glycoprotein CD1a (CD1A) Antibody
377€ (100 µg)
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Name
T-cell Surface Glycoprotein CD1a (CD1A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx231434
Tested Applications
ELISA, WB
Description
CD1A Antibody is a Rabbit Polyclonal against CD1A.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: T-cell Surface Glycoprotein CD1a (CD1A) Immunogen: CD1a molecule |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 65-70 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P06126 |
| Gene ID | 909 |
| OMIM | 188370 |
| Alias | R4,T6,CD1,FCB6,HTA1,T-cell surface glycoprotein CD1a,T-cell surface antigen T6/Leu-6,hTa1 thymocyte antigen |
| Background | Antibody anti-CD1A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD1a Molecule (CD1A) is a member of the CD1 family of glycoproteins involved in presenting lipid and glycolipid antigens to T cells. Expressed predominantly on the surface of dendritic cells, Langerhans cells, and thymocytes, CD1A plays a vital role in the immune system by bridging innate and adaptive immunity. Structurally, CD1A is similar to major histocompatibility complex (MHC) class I molecules but specializes in binding lipids and presenting them to a unique subset of T cells, particularly natural killer T (NKT) cells. This interaction is critical for initiating immune responses against certain pathogens, such as Mycobacterium tuberculosis and fungi, that contain unique lipid antigens. CD1A's role extends to the regulation of skin immunity, given its high expression in Langerhans cells within the epidermis. Dysregulation or altered expression of CD1A has been implicated in autoimmune disorders, certain cancers, and inflammatory skin diseases, such as psoriasis. It is also a marker used in histopathology to identify Langerhans cell histiocytosis and other immune-related conditions, highlighting its clinical and diagnostic importance.
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