T-Cell Differentiation Antigen CD6 (CD6) Antibody (PE)

429€ (100 tests)
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935106861
info@markelab.com
name
T-Cell Differentiation Antigen CD6 (CD6) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx139146
tested applications
FCM
Description
CD6 Antibody is a Mouse Monoclonal against CD6.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | T-Cell Differentiation Antigen CD6 (CD6) |
Host | Mouse |
Reactivity | Human |
Recommended Dilution | FCM: 20 µl/100 µl of whole blood or 106 cells. Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. The content of a vial (2 ml) is sufficient for 100 tests. |
Clonality | Monoclonal |
Conjugation | PE |
Isotype | IgG1 |
Clone ID | E350 |
Size 1 | 100 tests |
Tested Applications | FCM |
Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
Availability | Shipped within 5-12 working days. |
Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
Dry Ice | No |
UniProt ID | P30203 |
Gene ID | 923 |
Alias | TP120,T-cell differentiation antigen CD6,T12 |
Background | Antibody anti-CD6 |
Status | RUO |
Descripción
CD6 is a type I transmembrane glycoprotein expressed on the surface of T cells, some B cells, and a subset of natural killer (NK) cells. It plays a critical role in the modulation of immune responses, particularly in T-cell activation, differentiation, and immune synapse formation. CD6 is involved in regulating the threshold of T-cell receptor (TCR) signaling and acts as a co-stimulatory receptor that modulates immune responses. CD6 is expressed in the thymus, where it is involved in T-cell development, including positive and negative selection during thymic maturation. In peripheral tissues, CD6 helps facilitate immune responses against pathogens, while maintaining immune tolerance to self-antigens. Dysregulation of CD6 signaling is implicated in a range of immune-related conditions, including autoimmune diseases, inflammatory disorders, and certain types of cancer.
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