T-Cell Differentiation Antigen CD6 (CD6) Antibody
299€ (0.1 mg)
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935106861
info@markelab.com
name
T-Cell Differentiation Antigen CD6 (CD6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx139145
tested applications
WB, IHC, FCM, IP
Description
CD6 Antibody is a Mouse Monoclonal against CD6.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | T-Cell Differentiation Antigen CD6 (CD6) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB (Non-Reducing): 1-2 μg/ml, IHC-P: 10 μg/ml, FCM: 2 μg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | E350 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, IHC, FCM, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P30203 |
| Gene ID | 923 |
| Alias | TP120,T-cell differentiation antigen CD6,T12 |
| Background | Antibody anti-CD6 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
CD6 is a type I transmembrane glycoprotein expressed on the surface of T cells, some B cells, and a subset of natural killer (NK) cells. It plays a critical role in the modulation of immune responses, particularly in T-cell activation, differentiation, and immune synapse formation. CD6 is involved in regulating the threshold of T-cell receptor (TCR) signaling and acts as a co-stimulatory receptor that modulates immune responses. CD6 is expressed in the thymus, where it is involved in T-cell development, including positive and negative selection during thymic maturation. In peripheral tissues, CD6 helps facilitate immune responses against pathogens, while maintaining immune tolerance to self-antigens. Dysregulation of CD6 signaling is implicated in a range of immune-related conditions, including autoimmune diseases, inflammatory disorders, and certain types of cancer.
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