Switch-Associated Protein 70 (SWAP70) Antibody

Este producto es parte de SWAP70 - Switch-associated protein 70S
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416€ (200 µl)

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935106861
info@markelab.com
name
Switch-Associated Protein 70 (SWAP70) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433332
tested applications
P-ELISA, WB, IHC

Description

SWAP70 Antibody is a Goat Polyclonal antibody against SWAP70.

Documents del producto

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Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetSwitch-Associated Protein 70 (SWAP70)
HostGoat
ReactivityHuman
Recommended DilutionP-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Size 1200 µl
FormLiquid
Tested ApplicationsP-ELISA, WB, IHC
BufferTris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
NCBI AccessionNP_055870.2
AliasSWAP-70, HSPC321, SWAP switching B-cell complex 70kDa subunit, SWAP switching B-cell complex subunit 70, switching B-cell complex subunit switching B cell complex subunit SWAP70
BackgroundAntibody anti-SWAP70
StatusRUO
NoteConcentration: 0.5 mg/ml -

SWAP70 is a nuclear and cytoplasmic adaptor protein involved in actin cytoskeleton remodeling, signal transduction, and B-cell activation. It functions as a guanine nucleotide exchange factor (GEF) for Rac1, facilitating actin polymerization and cell shape changes during processes such as immune cell migration, phagocytosis, and endocytosis. SWAP70 plays a critical role in B-cell development, class switch recombination (CSR), and antigen receptor signaling, linking extracellular signals to cytoskeletal rearrangement and nuclear responses. It is expressed in hematopoietic cells, epithelial tissues, and immune cells, where it coordinates cell migration, adhesion, and immune responses. Dysregulation of SWAP70 is associated with autoimmune diseases, cancer metastasis, and inflammatory disorders due to impaired actin regulation and signaling balance. Knockout studies reveal defects in B-cell maturation, impaired immune cell migration, and reduced immune responses, highlighting its essential role in cytoskeletal remodeling, cell signaling, and adaptive immunity.

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