Suppressors of Cytokine Signaling 3 (Socs3) Antibody (Biotin)
169€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Suppressors of Cytokine Signaling 3 (Socs3) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx319709
Tested Applications
ELISA
Description
Socs3 Antibody (Biotin) is a Rabbit Polyclonal against Socs3 conjugated to Biotin.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Suppressors of Cytokine Signaling 3 (Socs3) Immunogen: Recombinant rat Suppressor of cytokine signaling 3 protein (1-225AA). |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O88583 |
| Gene ID | 89829 |
| Alias | CIS3,SSI3,ATOD4,Cish3,SSI-3,SOCS-3 |
| Background | Antibody anti-SOCS3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SOCS3 is a key negative regulator of cytokine signaling that inhibits JAK/STAT signaling pathways by binding to cytokine receptors, such as the IL-6 and leptin receptors, and targeting them for proteasomal degradation. It directly suppresses JAK kinase activity, preventing STAT phosphorylation and downstream signaling, which controls processes like inflammation, immune cell activation, and energy homeostasis. SOCS3 is highly expressed in immune cells, adipose tissues, and liver, where it modulates cytokine responses, insulin sensitivity, and metabolic regulation. It is critical for limiting excessive inflammation during infections and preventing chronic inflammatory diseases. Dysregulation of SOCS3 is implicated in autoimmune diseases, metabolic disorders like obesity and insulin resistance, and cancer, where it affects cytokine balance and cellular proliferation. Knockout studies reveal embryonic lethality, hyperactivated cytokine signaling, and increased susceptibility to inflammatory and metabolic diseases, underscoring its pivotal role in immune regulation and cytokine signaling control.
Productos relacionados
Suppressors of Cytokine Signaling 3 (SOCS3) Antibody
SOCS3 Antibody is a Rabbit Polyclonal antibody against SOCS3. This gene encodes a member of the STAT-induced STAT inhibi…
Ver producto
Suppressors of Cytokine Signaling 3 (SOCS3) Antibody
SOCS3 Antibody is a Rabbit Polyclonal antibody against SOCS3. The suppressor of cytokine signaling (SOCS) family protein…
Ver producto Suppressors of Cytokine Signaling 3 (SOCS3) Antibody
Rabbit Polyclonal against the SOCS3 protein.…
Ver producto