Suppressors of Cytokine Signaling 3 (SOCS3) Antibody
273€ (100 µl)
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935106861
info@markelab.com
name
Suppressors of Cytokine Signaling 3 (SOCS3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx128584
tested applications
WB
Description
Suppressors Of Cytokine Signaling 3 Antibody is a Rabbit Polyclonal against Suppressors Of Cytokine Signaling 3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Suppressors of Cytokine Signaling 3 (SOCS3) Immunogen: abx166629 - Recombinant SOCS3 (Met1-Leu225) expressed in E. coli |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 0.77 mg/ml |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14543 |
| Alias | CIS3,SSI3,ATOD4,Cish3,SSI-3,SOCS-3 |
| Background | Antibody anti-SOCS3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
SOCS3 is a key negative regulator of cytokine signaling that inhibits JAK/STAT signaling pathways by binding to cytokine receptors, such as the IL-6 and leptin receptors, and targeting them for proteasomal degradation. It directly suppresses JAK kinase activity, preventing STAT phosphorylation and downstream signaling, which controls processes like inflammation, immune cell activation, and energy homeostasis. SOCS3 is highly expressed in immune cells, adipose tissues, and liver, where it modulates cytokine responses, insulin sensitivity, and metabolic regulation. It is critical for limiting excessive inflammation during infections and preventing chronic inflammatory diseases. Dysregulation of SOCS3 is implicated in autoimmune diseases, metabolic disorders like obesity and insulin resistance, and cancer, where it affects cytokine balance and cellular proliferation. Knockout studies reveal embryonic lethality, hyperactivated cytokine signaling, and increased susceptibility to inflammatory and metabolic diseases, underscoring its pivotal role in immune regulation and cytokine signaling control.
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Human Suppressors Of Cytokine Signaling 3 (SOCS3) Protein
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