Suppressor of Cytokine Signaling 7 (SOCS7) Antibody
442€ (200 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Suppressor of Cytokine Signaling 7 (SOCS7) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433300
tested applications
P-ELISA, WB
Description
SOCS7 Antibody is a Goat Polyclonal antibody against SOCS7.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Suppressor of Cytokine Signaling 7 (SOCS7) Immunogen: abx615709 - Internal region: C-DAGRKPKLTRTQS |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 30837 |
| NCBI Accession | NP_055413.1 |
| Alias | SOCS7, NAP4, NCKAP4, suppressor of cytokine signaling 7,nck |
| Background | Antibody anti-SOCS7 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
SOCS7 is a member of the SOCS family that negatively regulates cytokine signaling pathways, particularly those involving the JAK/STAT pathway, by targeting receptor complexes and downstream components for proteasomal degradation via its SOCS box. Unlike other SOCS proteins, SOCS7 has additional roles in regulating insulin signaling, cellular localization of signaling proteins, and DNA damage responses. SOCS7 interacts with the nuclear adaptor protein NCK and modulates actin cytoskeletal dynamics, cell polarity, and nuclear signaling. It is highly expressed in tissues such as the brain, pancreas, and immune cells, where it participates in processes like insulin homeostasis, cell migration, and cytokine regulation. Dysregulation of SOCS7 is associated with metabolic disorders, insulin resistance, and immune dysfunction. Knockout studies reveal defects in glucose homeostasis, increased susceptibility to DNA damage, and disrupted immune responses, highlighting its multifunctional role in cytokine signaling, metabolism, and cell signaling regulation.
Related Products
Suppressor of Cytokine Signaling 7 (SOCS7) Peptide
Suppressor of Cytokine Signaling 7 (SOCS7) Peptide is a synthetic peptide. This peptide is used in the production of
Ver Producto