Suppressor of Cytokine Signaling 4 (SOCS4) Antibody
442€ (200 µl)
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Name
Suppressor of Cytokine Signaling 4 (SOCS4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx433299
Tested Applications
P-ELISA, IHC
Description
SOCS4 Antibody is a Goat Polyclonal antibody against SOCS4.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Suppressor of Cytokine Signaling 4 (SOCS4) Immunogen: abx269124 - C-Terminus: C-SKVRVLRIDAPEQQ |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 122809 |
| NCBI Accession | NP_543143.1, NP_955453.1 |
| Alias | SOCS-4,Suppressor of cytokine signaling 7,SOCS-7 |
| Background | Antibody anti-SOCS4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SOCS4 is a member of the SOCS protein family that regulates cytokine signaling by inhibiting the Janus kinase (JAK)/STAT pathway and promoting the proteasomal degradation of signaling intermediates via its SOCS box domain. It interacts with phosphorylated cytokine receptors and downstream proteins to suppress excessive cytokine responses, particularly in pathways related to epidermal growth factor receptor (EGFR) and interleukin-4 (IL-4). SOCS4 is broadly expressed in tissues such as the liver, immune cells, and epithelial tissues, where it regulates processes like cell proliferation, differentiation, and immune homeostasis. It has been implicated in regulating inflammation and epithelial repair during infections. Dysregulation of SOCS4 is linked to chronic inflammation, impaired wound healing, and cancer progression, where excessive EGFR signaling promotes uncontrolled cell proliferation. Knockdown studies reveal hyperactivated cytokine signaling, increased inflammatory responses, and abnormal cellular growth, highlighting its critical role in balancing cytokine-mediated signaling pathways.
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