Src Kinase-Associated Phosphoprotein 2 (SKAP2) Antibody

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Description
Src Kinase-Associated Phosphoprotein 2 (SKAP2) Antibody is a Rabbit polyclonal antibody for the detection of Human Src Kinase-Associated Phosphoprotein 2 (SKAP2).
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Product specifications
Category | Primary Antibodies |
Immunogen Target | Src Kinase-Associated Phosphoprotein 2 (SKAP2) |
Host | Rabbit |
Reactivity | Human |
Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Size 1 | 50 µg |
Size 2 | 100 µg |
Form | Liquid |
Tested Applications | ELISA, WB, IHC |
Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
Availability | Shipped within 5-12 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | O75563 |
Gene ID | 8935 |
NCBI Accession | NP_001290397.1 |
Background | Antibody anti-SKAP2 |
Status | RUO |
Descripción
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The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms.
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