SOCS7 Antibody (Biotin)
169€ (20 µg)
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935106861
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name
SOCS7 Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx317216
tested applications
ELISA
Description
SOCS7 Antibody (Biotin) is a Rabbit Polyclonal against SOCS7 conjugated to Biotin.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SOCS7 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14512 |
| Gene ID | 30837 |
| NCBI Accession | NP_055413.1, NM_014598.3 |
| OMIM | 608788 |
| Alias | SOCS7, NAP4, NCKAP4, suppressor of cytokine signaling 7,nck |
| Background | Antibody anti-SOCS7 |
| Status | RUO |
Descripción
SOCS7 is a member of the SOCS family that negatively regulates cytokine signaling pathways, particularly those involving the JAK/STAT pathway, by targeting receptor complexes and downstream components for proteasomal degradation via its SOCS box. Unlike other SOCS proteins, SOCS7 has additional roles in regulating insulin signaling, cellular localization of signaling proteins, and DNA damage responses. SOCS7 interacts with the nuclear adaptor protein NCK and modulates actin cytoskeletal dynamics, cell polarity, and nuclear signaling. It is highly expressed in tissues such as the brain, pancreas, and immune cells, where it participates in processes like insulin homeostasis, cell migration, and cytokine regulation. Dysregulation of SOCS7 is associated with metabolic disorders, insulin resistance, and immune dysfunction. Knockout studies reveal defects in glucose homeostasis, increased susceptibility to DNA damage, and disrupted immune responses, highlighting its multifunctional role in cytokine signaling, metabolism, and cell signaling regulation.
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