Signal Transducer And Activator Of Transcription 2 (STAT2) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Signal Transducer And Activator Of Transcription 2 (STAT2) Antibody is a Rabbit polyclonal antibody for the detection of Human Signal Transducer And Activator Of Transcription 2 (STAT2).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Signal Transducer And Activator Of Transcription 2 (STAT2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to 2 weeks. For long-term storage, aliquot and store at -80 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P52630 |
| Gene ID | 6773 |
| NCBI Accession | NP_005410.1 |
| Background | Antibody anti-STAT2 |
| Status | RUO |
Descripción
Related Products
Human STAT2 (Signal transducer and activator of transcription 2) ELISA Kit
Ver Producto
Mouse STAT2 (Signal Transducer And Activator Of Transcription 2) ELISA Kit
Ver Producto
STAT2 antibody
Signal transducer and activator of transcription that mediates signaling by type I IFNs(IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases(TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element(ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state(PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively(PubMed:26122121).
Ver Producto