Signal Transducer and Activator of Transcription 1 (STAT1) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
STAT1 Antibody is a Rabbit Polyclonal against STAT1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Signal Transducer and Activator of Transcription 1 (STAT1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/500 - 1/2000, WB: 1/250 - 1/1000, IHC: 1/15 - 1/60. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P42224 |
| Gene ID | 6772 |
| Background | Antibody anti-STAT1 |
| Status | RUO |
Descripción
Related Products
Human STAT1 (Signal Transducer and Activator of Transcription 1) ELISA Kit
Ver Producto
Mouse STAT1 (Signal Transducer And Activator Of Transcription 1) ELISA Kit
Ver Producto
STAT1 antibody
Signal transducer and transcription activator that mediates cellular responses to interferons(IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN(IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases(TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element(ISRE) to activate the transcription of IFN-stimulated genes(ISG), which drive the cell in an antiviral state. In response to type II IFN(IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor(GAF), migrates into the nucleus and binds to the IFN gamma activated sequence(GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Ver Producto