Signal Regulatory Protein Alpha (SIRPA) Antibody
169€ (20 µg)
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name
Signal Regulatory Protein Alpha (SIRPA) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx301282
tested applications
ELISA, IHC, IF/ICC
Description
SIRPA Antibody is a Rabbit Polyclonal against SIRPA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Signal Regulatory Protein Alpha (SIRPA) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P78324 |
| Gene ID | 140885 |
| OMIM | 602461 |
| Alias | Tyrosine-protein phosphatase non-receptor type substrate 1,BIT,MFR,P84,SIRP,MYD-1,SHPS1,CD172A,PTPNS1,SHP substrate 1,SHPS-1,Brain Ig-like molecule with tyrosine-based activation motifs,Inhibitory receptor SHPS-1,Macrophage fusion receptor,MyD-1 antigen |
| Background | Antibody anti-SIRPA |
| Status | RUO |
Descripción
Signal regulatory protein alpha (SIRPA) is a transmembrane glycoprotein encoded by the SIRPA gene in humans, primarily expressed on myeloid cells such as macrophages, dendritic cells, and neutrophils, and to a lesser extent on neurons. SIRPA belongs to the immunoglobulin superfamily (IgSF) and functions as an inhibitory receptor, playing a critical role in immune homeostasis, cellular signaling, and cell-cell interactions. SIRPA interacts primarily with CD47, a widely expressed protein known as the “don’t eat me” signal on host cells. This interaction is fundamental for immune surveillance, as it prevents macrophages and other immune cells from targeting healthy self-cells for phagocytosis, thereby maintaining tolerance to self while supporting immune responses against foreign antigens and damaged cells. SIRPA is integral in modulating immune responses and is implicated in a range of physiological processes, including cell migration, cell adhesion, and tissue homeostasis. Research indicates that SIRPA is not only crucial in the innate immune system but also impacts adaptive immunity. Dysregulation or mutations of SIRPA have been linked to autoimmunity, cancer, and other pathologies due to its role in immune evasion, particularly in the context of cancer, where many tumor cells upregulate CD47 to escape immune clearance.
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