Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8) Antibody
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935106861
info@markelab.com
Precio
387.5€ (200 µl)
Antibody anti-SIGLEC8
proveedor
Abbexareference
abx433273Tested Applications
P-ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
SIGLEC8 Antibody is a Goat Polyclonal antibody against SIGLEC8.
Background
SIGLEC8 is an inhibitory receptor expressed mainly on eosinophils, mast cells, and basophils. It binds selectively to 6′-sulfated sialyl Lewis X and related glycan ligands, regulating inflammatory responses in allergic diseases. Activation of SIGLEC8 leads to eosinophil apoptosis and inhibition of mast cell degranulation, making it an attractive therapeutic target for asthma and eosinophilic disorders. Its function is mediated through ITIMs, which dampen cell activation pathways. SIGLEC8 is also implicated in maintaining immune homeostasis in tissues and resolving allergic inflammation.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8)
host
Goat
conjugation
Unconjugated
form
Liquid
tested applications
P-ELISA, WB
purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
size 1
200 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
SIGLEC8
dry ice
No
availability
Shipped within 1-3 working days.
alias
SAF2,SIGLEC-8,SIGLEC8L,Sialoadhesin family member 2
NCBI accession
NP_055257.2
note
This product is for research use only.
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