Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Antibody (Biotin)

Este producto es parte de SIGLEC - sialic acid binding Ig like lectin
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377€ (200 µl)

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935106861
info@markelab.com
name
Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx272457
tested applications
WB, IHC, IF/ICC

Description

Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5).

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetSialic Acid Binding Ig Like Lectin 5 (SIGLEC5)
HostRabbit
ReactivityHuman
Recommended DilutionWB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationBiotin
IsotypeIgG
PurificationPurified by antigen-specific affinity chromatography.
Size 1200 µl
Size 21 ml
FormLiquid
Tested ApplicationsWB, IHC, IF/ICC
Buffer0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
AvailabilityShipped within 5-15 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
AliasCD170,OBBP2,CD33L2,OB-BP2,SIGLEC-5,Obesity-binding protein 2,CD33 antigen-like 2
BackgroundAntibody anti-SIGLEC5
StatusRUO

Descripción

SIGLEC5 is an inhibitory receptor expressed on monocytes, neutrophils, and B cells. It binds to sialic acid-containing glycans on host and microbial surfaces, modulating immune responses to avoid excessive inflammation. Through its immunoreceptor tyrosine-based inhibitory motifs (ITIMs), SIGLEC5 dampens activation signals and helps maintain immune tolerance. This protein also plays a role in preventing inappropriate immune responses during pregnancy and infection. Genetic fusion events between SIGLEC5 and SIGLEC14 have been noted, affecting the functional balance between activation and inhibition. SIGLEC5 is studied for its involvement in autoimmune diseases and infections.

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