Sialic Acid Binding Ig Like Lectin 2 (SIGLEC2) Antibody
273€ (100 µl)
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935106861
info@markelab.com
name
Sialic Acid Binding Ig Like Lectin 2 (SIGLEC2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104091
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 2 (SIGLEC2).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Sialic Acid Binding Ig Like Lectin 2 (SIGLEC2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P20273 |
| Alias | SIGLEC2,SIGLEC-2,B-cell receptor CD22,B-lymphocyte cell adhesion molecule,BL-CAM,Sialic acid-binding Ig-like lectin 2,T-cell surface antigen Leu-14 |
| Background | Antibody anti-CD22 |
| Status | RUO |
Descripción
CD22, also known as Siglec-2, is a member of the sialic acid-binding immunoglobulin-like lectins (Siglec) family and is predominantly expressed on B cells. It plays a crucial role in modulating B-cell receptor (BCR) signaling and maintaining B-cell tolerance, making it an essential molecule in the regulation of the immune system. CD22 is primarily found on mature B cells, acting both as an inhibitory coreceptor to dampen BCR signaling and as an adhesion molecule involved in cell-cell interactions. CD22 is essential for maintaining the delicate balance between immune activation and tolerance, preventing excessive immune responses that could lead to autoimmune diseases. It is an inhibitory receptor that modulates B-cell activity by recruiting SHP-1, a phosphatase that negatively regulates B-cell signaling pathways. In this capacity, CD22 fine-tunes the immune response to antigens, ensuring that B cells are appropriately activated and preventing autoimmunity.
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