Sheep Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1) ELISA Kit

Este producto es parte de FLT1 - fms related receptor tyrosine kinase 1
Sheep Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1) ELISA Kit
741€ (96 tests)

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Name
Sheep Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx364714
Tested Applications
ELISA

Description

Sheep Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Sheep Vascular Endothelial Growth Factor Receptor 1 (FLT1 / VEGFR1) concentrations in serum, plasma, tissue homogenates and other biological fluids.

Documentos del producto

Instrucciones
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Data sheet
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Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1)
Reactivity
Sheep
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Sensitivity
< 0.07 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Serum, plasma, tissue homogenates and other biological fluids.
Availability
Shipped within 5-7 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
FLT,FLT-1,VEGFR1,VEGFR-1,Vascular permeability factor receptor,Fms-like tyrosine kinase 1,Vascular endothelial growth factor receptor 1
Background
Elisa Kits for: FLT1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

Fms related receptor tyrosine kinase 1 (FLT1) FLT1, also known as vascular endothelial growth factor receptor 1 (VEGFR1), is a transmembrane tyrosine kinase receptor that binds vascular endothelial growth factors (VEGFs) and placental growth factor (PlGF). FLT1 plays a crucial role in angiogenesis, vascular development, and inflammation by regulating endothelial cell proliferation, migration, and survival. Structurally, FLT1 consists of an extracellular ligand-binding domain with seven immunoglobulin-like loops, a transmembrane domain, and an intracellular kinase domain. FLT1 can function as a signaling receptor or a decoy receptor, depending on its membrane-bound or soluble isoforms, modulating VEGF availability and signaling intensity. It is highly expressed in endothelial cells and trophoblasts, contributing to processes such as placental development and vascular remodeling. Dysregulation of FLT1 is implicated in pathological conditions, including cancer, where it promotes tumor angiogenesis, and preeclampsia, where excessive FLT1 activity leads to impaired placental and vascular function. Its dual role as a regulator of VEGF signaling and a therapeutic target underscores its importance in both physiological and pathological angiogenesis.

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