SH2 domain-containing protein 3A (SH2D3A) Antibody (FITC)
260€ (50 µl)
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935106861
info@markelab.com
name
SH2 domain-containing protein 3A (SH2D3A) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx349196
Description
SH2 domain-containing protein 3A (SH2D3A) Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC for the detection of Human SH2D3A.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH2 domain-containing protein 3A (SH2D3A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 1 ml |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BRG2 |
| Gene ID | 10045 |
| OMIM | 604721 |
| Alias | SH2D3A, NSP1, SH2 domain containing 3A |
| Background | Antibody anti-SH2D3A |
| Status | RUO |
Descripción
SH2D3A, also known as NSP1 (novel SH2-containing protein 1), is an adaptor protein containing an SH2 domain and a proline-rich region that mediates interactions with signaling molecules in receptor tyrosine kinase pathways. It is involved in regulating actin cytoskeletal remodeling, cell adhesion, and migration by linking signaling proteins like Crk-associated substrates (CAS) to downstream effectors. SH2D3A plays a key role in integrin-mediated signaling and growth factor receptor activation, particularly during cell motility and adhesion processes. It is highly expressed in tissues undergoing dynamic changes, such as embryonic development and wound healing. Dysregulation of SH2D3A has been linked to cancer progression, where it promotes metastasis and invasion through actin cytoskeletal reorganization and integrin activation. Knockout studies reveal defects in cell migration, adhesion, and spreading, underscoring its importance in cellular movement and signal transduction.
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