Sestrin 3 (SESN3) Antibody
292.5€ (80 µl)
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name
Sestrin 3 (SESN3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx026835
tested applications
ELISA, WB, IHC
Description
Sestrins form a small family of redox enzymes which regulate accumulation of Reactive Oxygen Species. They protect cells and their DNA against oxidative damage and regulate cell growth and viability. These genes are often deregulated in cancers and their inactivation accelerates the growth of model tumors in mice.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Sestrin 3 (SESN3) Immunogen: KLH-conjugated synthetic peptide between 320-347 amino acids from the Central region of human Sestrin-3. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/2000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 57.3 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P58005 |
| Alias | SEST3 |
| Background | Antibody anti-SESN3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
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SESN3 antibody
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway(PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2(By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses(By similarity).
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