Sestrin 3 (SESN3) Antibody
312€ (60 µl)
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935106861
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name
Sestrin 3 (SESN3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx003957
tested applications
WB
Description
SESN3 Antibody is a Rabbit Polyclonal antibody against SESN3. This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Sestrin 3 (SESN3) Immunogen: Recombinant fusion protein corresponding to human SESN3 |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 36 kDa/41 kDa/57 kDa Observed MW: 50 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P58005 |
| Gene ID | 143686 |
| NCBI Accession | NP_653266.2 |
| Alias | SEST3 |
| Background | Antibody anti-SESN3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
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May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway(PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2(By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses(By similarity).
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