Polyclonal Antibody to Serum Amyloid P Component (SAP).
SAP, also known as PTX2, belongs to the pentraxin family. Has the ability to bind ligands in a calcium-dependent manner and its unique flattened β-jellyroll structure, which bears resemblance to the structure found in legume lectins. APCS is its human gene.SAP is exclusively produced in the liver, and as a standard plasma protein, it is naturally present in all individuals. While it enters the brain in only minuscule quantities under normal conditions, it is consistently found in the cerebrospinal fluid. AP possesses the capacity to bind to both amyloid plaques and tau tangles, effectively stabilizing and stabilise aggregates by preventing proteolytic cleavage and hence inhibiting fibril removal. It ia also known as: APCS, PTX2, SAP, AP, Amyloid P Component
SAP, también conocida como PTX2, pertenece a la familia de las pentraxinas. Tiene la capacidad de unirse a ligandos de una manera dependiente del calcio y su estructura única de β-jellyroll aplanada, que se parece a la estructura que se encuentra en las lectinas de las leguminosas. APCS es su gen humano. La SAP se produce exclusivamente en el hígado y, como proteína plasmática estándar, está presente de forma natural en todos los individuos. Si bien ingresa al cerebro sólo en cantidades minúsculas en condiciones normales, se encuentra constantemente en el líquido cefalorraquídeo. AP posee la capacidad de unirse tanto a placas amiloides como a ovillos de tau, estabilizando y estabilizando eficazmente los agregados al prevenir la escisión proteolítica y, por lo tanto, inhibir la eliminación de fibrillas. También se conoce como: APCS, PTX2, SAP, AP, componente amiloide P.
Primary Antibodies
Polyclonal
Rat
Serum Amyloid P Component (SAP)
Rabbit
Unconjugated
Liquid
WB, IHC, IF/ICC
Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
100 µl
200 µl
1 ml
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
SAP
No
Shipped within 5-7 working days.
This product is for research use only.
Precio a consultar
Ver másHuman Serum Amyloid P Component (SAP) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay...
812.5€ (96 tests)
Ver másAPCS Antibody is a Rabbit Polyclonal against APCS.
237.5€ (50 µl)
Ver más