Serum Amyloid P-Component (APCS) Antibody

Pida mas información

935106861

info@markelab.com

Precio

612.5€ (100 µl)

proveedor

Abbexa

reference

abx110961

Tested Applications

ELISA, WB

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

Amyloid P Component, Serum Antibody is a Rabbit Polyclonal antibody against Amyloid P Component, Serum.

Background

SAP, also known as PTX2, belongs to the pentraxin family. Has the ability to bind ligands in a calcium-dependent manner and its unique flattened β-jellyroll structure, which bears resemblance to the structure found in legume lectins. APCS is its human gene.SAP is exclusively produced in the liver, and as a standard plasma protein, it is naturally present in all individuals. While it enters the brain in only minuscule quantities under normal conditions, it is consistently found in the cerebrospinal fluid. AP possesses the capacity to bind to both amyloid plaques and tau tangles, effectively stabilizing and stabilise aggregates by preventing proteolytic cleavage and hence inhibiting fibril removal. It ia also known as: APCS, PTX2, SAP, AP, Amyloid P Component

Background

SAP, también conocida como PTX2, pertenece a la familia de las pentraxinas. Tiene la capacidad de unirse a ligandos de una manera dependiente del calcio y su estructura única de β-jellyroll aplanada, que se parece a la estructura que se encuentra en las lectinas de las leguminosas. APCS es su gen humano. La SAP se produce exclusivamente en el hígado y, como proteína plasmática estándar, está presente de forma natural en todos los individuos. Si bien ingresa al cerebro sólo en cantidades minúsculas en condiciones normales, se encuentra constantemente en el líquido cefalorraquídeo. AP posee la capacidad de unirse tanto a placas amiloides como a ovillos de tau, estabilizando y estabilizando eficazmente los agregados al prevenir la escisión proteolítica y, por lo tanto, inhibir la eliminación de fibrillas. También se conoce como: APCS, PTX2, SAP, AP, componente amiloide P.

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

Serum Amyloid P-Component (APCS)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB

purification

Antigen Affinity Chromatography.

buffer

PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol.

size 1

100 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

APCS

dry ice

availability

Shipped within 5-10 working days.

alias

APCS,PTX2,Ptx2,Sap

uniprot id

https://www.uniprot.org/uniprotkb/P02743

gene id

https://www.ncbi.nlm.nih.gov/gene/325

note

This product is for research use only.

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