Serum Amyloid A4, Constitutive (SAA4) Antibody
proveedor
Abbexareference
abx174526Tested Applications
WB, IHC, IF/ICCreactivity
Humanstatus
RUOclonality
MonoclonalDescripción
This product is currently in development. The lead time for this product may be several months. Please contact us at info@markelab.com for an updated lead time before purchasing this product. Serum Amyloid A4, Constitutive (SAA4) Antibody is a Mouse Monoclonal antibody against Serum Amyloid A4, Constitutive (SAA4).
Background
SAA proteins, belong to a family of apolipoproteins found in association with high-density lipoprotein (HDL) in plasma. These SAA proteins, consisting of 104 amino acids, are encoded within a closely-related gene family and have remained remarkably conserved throughout the course of vertebrate evolution. Notably, fragments of SAA at their amino-terminal end can aggregate into highly structured, insoluble fibrils that accumulate in what is referred to as "secondary" amyloid diseases. In mice, three acute-phase SAA isoforms have been identified, (SAA1, SAA2, and SAA3). During episodes of inflammation, SAA1 and SAA2 are primarily expressed and induced in the liver, whereas SAA3 sees induction in various distinct tissues. In contrast, humans possess a fourth SAA, known as SAA4, which is constitutively expressed in the liver and is thus categorized as constitutive SAA (C-SAA). It's worth noting that a similar protein, now also referred to as SAA4, has been identified in mice
Background
Las proteínas SAA pertenecen a una familia de apolipoproteínas que se encuentran asociadas con las lipoproteínas de alta densidad (HDL) en el plasma. Estas proteínas SAA, que constan de 104 aminoácidos, están codificadas dentro de una familia de genes estrechamente relacionada y se han conservado notablemente a lo largo de la evolución de los vertebrados. En particular, los fragmentos de SAA en su extremo amino terminal pueden agregarse en fibrillas insolubles altamente estructuradas que se acumulan en lo que se conoce como enfermedades amiloides "secundarias". En ratones, se han identificado tres isoformas de SAA de fase aguda (SAA1, SAA2 y SAA3). Durante los episodios de inflamación, SAA1 y SAA2 se expresan e inducen principalmente en el hígado, mientras que SAA3 se induce en varios tejidos distintos. Por el contrario, los seres humanos poseen un cuarto SAA, conocido como SAA4, que se expresa constitutivamente en el hígado y, por tanto, se clasifica como SAA constitutivo (C-SAA). Vale la pena señalar que se ha identificado en ratones una proteína similar, ahora también conocida como SAA4.
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Human
immunogen target
Serum Amyloid A4, Constitutive (SAA4)
host
Mouse
conjugation
Unconjugated
form
Liquid
tested applications
WB, IHC, IF/ICC
purification
Purified by Protein A and Protein G affinity chromatography.
buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
size 1
1 ml
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
SAA4
dry ice
No
availability
Please enquire.
note
This product is for research use only.
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