Serpin I2 (SERPINI2) Antibody
292.5€ (80 µl)
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name
Serpin I2 (SERPINI2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx029696
tested applications
ELISA, WB
Description
The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Serpin I2 (SERPINI2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75830 |
| Alias | MEPI,PI14,PANCPIN,TSA2004,Serpin I2,Myoepithelium-derived serine protease inhibitor,Pancpin,Peptidase inhibitor 14 |
| Background | Antibody anti-SERPINI2 |
| Status | RUO |
Descripción
SERPINI2 is a member of the serine protease inhibitor (serpin) family and is encoded by the SERPINI2 gene located on chromosome 3. The serpin superfamily comprises a large group of proteins that inhibit proteolytic enzymes, playing crucial roles in various biological processes such as blood coagulation, fibrinolysis, immune response, and tissue remodeling. Like other serpins, SERPINI2 regulates the activity of proteases by acting as a suicide substrate, forming a stable complex with the target protease, which leads to its irreversible inhibition. Although SERPINI2 is not as well-studied as other members of the serpin family, recent studies suggest that it is involved in the regulation of proteolysis in various tissues, with significant expression observed in pancreatic, hepatic, and other glandular tissues.
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