Alpha-1-Antichymotrypsin (SERPINA3) Antibody
proveedor
Abbexareference
abx339692Tested Applications
ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
SERPINA3 Antibody is a Rabbit Polyclonal against SERPINA3.
Background
Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL). SERPINA3, also called α-1-antichymotrypsin (AACT, ACT), is one of the inhibitors of serine proteases, one of which is cathepsin G. Elevated levels of SERPINA3 have been observed in heart failure and neurological diseases such as Alzheimer’s disease
Background
Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle del centro reactivo (RCL). SERPINA3, también llamada α-1-antiquimotripsina (AACT, ACT), es uno de los inhibidores de las serina proteasas, una de las cuales es la catepsina G. Se han observado niveles elevados de SERPINA3 en insuficiencia cardíaca y enfermedades neurológicas como la enfermedad de Alzheimer.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Alpha-1-Antichymotrypsin (SERPINA3)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Antigen Affinity Chromatography.
buffer
PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol.
size 1
50 µl
size 2
100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
SERPINA3
dry ice
No
availability
Shipped within 5-10 working days.
alias
ACT,AACT,GIG24,GIG25,Alpha-1-antichymotrypsin,Cell growth-inhibiting gene 24/25 protein,Serpin A3
uniprot id
NCBI accession
NP_001076.2, NM_001085.4
note
This product is for research use only.
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