Serpin B9 (SERPINB9) Antibody
520€ (100 µg)
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935106861
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name
Serpin B9 (SERPINB9) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx414334
tested applications
WB, IHC, FCM
Description
Serpin B9 (SERPINB9) Antibody is a Mouse Monoclonal antibody against PI-9.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Serpin B9 (SERPINB9) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | IHC-P: 1/50, FCM: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | C500 |
| Purification | Purified from tissue culture supernatant by Protein G affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | WB, IHC, FCM |
| Buffer | PBS. Contains 0.09% sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P50453 |
| Alias | PI9,CAP3,PI-9,CAP-3,Serpin B9,Cytoplasmic antiproteinase 3,Peptidase inhibitor 9 |
| Background | Antibody anti-SERPINB9 |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
SERPINB9, also known as Cytoplasmic Antiproteinase 9 (CAP9) or PI-9, is a member of the serpin (serine protease inhibitor) superfamily. This protein plays a critical role in protecting cells from granzyme B, a serine protease involved in inducing apoptosis in target cells. Granzyme B is a key component of the immune system's cytotoxic mechanisms, primarily used by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells to eliminate infected or transformed cells. SERPINB9 is encoded by the SERPINB9 gene, which is located on chromosome 6p25. The protein has been highly conserved throughout evolution, underscoring its vital role in immune regulation. Unlike many other serpins that operate extracellularly, SERPINB9 is an intracellular serpin, making it an integral component of cellular defense mechanisms against protease-mediated apoptosis.
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