Serine/Threonine-Protein Kinase LMTK1 (AATK) Antibody
260€ (100 µl)
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935106861
info@markelab.com
name
Serine/Threonine-Protein Kinase LMTK1 (AATK) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx128704
tested applications
WB, IHC, IF/ICC
Description
Apoptosis Associated Tyrosine Kinase Antibody is a Rabbit Polyclonal against Apoptosis Associated Tyrosine Kinase.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Serine/Threonine-Protein Kinase LMTK1 (AATK) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6ZMQ8 |
| Gene ID | 9625 |
| NCBI Accession | NM_001080395 |
| OMIM | 605276 |
| Alias | AATYK,AATYK1,LMR1,LMTK1,PPP1R77,P35bp,AATK |
| Background | Antibody anti-AATK |
| Status | RUO |
Descripción
AATK (Apoptosis-Associated Tyrosine Kinase), also known as LMTK1 (Lemur Tyrosine Kinase 1), is a member of the serine/threonine-protein kinase family. PTKs (Protein Tyrosine Kinases) facilitate the transfer of the gamma-phosphoryl group from ATP to tyrosine (Tyr) residues. LMTK1, also known as Apoptosis-associated tyrosine kinase (AATK) or AATYK, is a cytoplasmic kinase with an extensive C-terminal region. The expression of LMTK1 is elevated during growth arrest and apoptosis in myeloid cells . LMTK1 is implicated in neural differentiation and serves as a regulator for the Na-K-2Cl cotransporter, a membrane protein involved in cell proliferation, survival, epithelial transport, and blood pressure control. The protein comprises a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. Studies on the mouse homologue suggest its potential role in inducing growth arrest and apoptosis in myeloid precursor cells. Additionally, it may play a part in promoting differentiation in neuronal cells . Recent reports also highlight its suppressive effect on melanoma development
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