Serine/Threonine-Protein Kinase CHK2 (CHEK2) Cell ELISA Kit

Product Graph
513.5€ (96 tests)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Serine/Threonine-Protein Kinase CHK2 (CHEK2) Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595119
tested applications
ELISA

Description

Chk2 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Serine/Threonine-Protein Kinase CHK2 (CHEK2)
Reactivity
Human, Mouse, Rat
Detection Method
Colorimetric
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Tested Applications
ELISA
Availability
Shipped within 1-2 weeks. The validity for this kit is at least 6 months
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
O96017
Gene ID
11200
OMIM
114480
Background
Elisa kits for CHEK2
Status
RUO
Note
Validity: 6 months.

This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Related Products

FNab01654

CHEK2 antibody

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.

Ver Producto
P2327

Recombinant Human CHEK2

Ver Producto
abx012469

Serine/Threonine-Protein Kinase CHK2 Phospho-Thr383 (CHEK2 pT383) Antibody

Rabbit polyclonal antibody against Chk2 protein. Immunogen region is Internal. Specificity is as follows for the reactive species: H:T383, M:T387, R:T386.

Ver Producto