Serine/Threonine-Protein Kinase CHK2 (CHEK2) Cell ELISA Kit

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Chk2 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Product specifications
Category | ELISA Kits |
Immunogen Target | Serine/Threonine-Protein Kinase CHK2 (CHEK2) |
Reactivity | Human, Mouse, Rat |
Detection Method | Colorimetric |
Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
Size 1 | 96 tests |
Tested Applications | ELISA |
Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
Dry Ice | No |
UniProt ID | O96017 |
Gene ID | 11200 |
OMIM | 114480 |
Background | Elisa kits for CHEK2 |
Status | RUO |
Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Related Products

CHEK2 antibody
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.
Ver Producto
Recombinant Human CHEK2
Ver Producto
Serine/Threonine-Protein Kinase CHK2 Phospho-Thr383 (CHEK2 pT383) Antibody
Rabbit polyclonal antibody against Chk2 protein. Immunogen region is Internal. Specificity is as follows for the reactive species: H:T383, M:T387, R:T386.
Ver Producto