Sequestosome 1 (SQSTM1) Antibody

Descripción

SQSTM1/p62 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. This protein may play a role in titin/TTN downstream signaling in muscle cells, and may also regulate signaling cascades through ubiquitination. This protein is involved in cell differentiation, apoptosis, immune response and regulation of K (+) channels. SQSTM1/p62 also appears to play a role in macroautophagic removal of intracellular protein aggregates. Cellular depletion studies of SQSTM1/p62 have indicated a role for association with LC3 and aggregate proteins in order to facilitate normal formation of the autophagosome.

Características del producto

clonality

Polyclonal

reactivity

Human, Mouse

immunogen target

Sequestosome 1 (SQSTM1)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB, IHC, IF/ICC

purification

Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

buffer

PBS containing 0.09% sodium azide.

size 1

80 µl

size 2

400 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

SQSTM1

dry ice

availability

Shipped within 5-10 working days.

alias

SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3, NADGP, DMRV

uniprot id

https://www.uniprot.org/uniprotkb/Q13501

NCBI accession

NP_001135770.1, NP_001135771.1, NP_003891.1

note

This product is for research use only.

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proveedor

FineTest

reference

P0752

Tested Applications

Western Blot, ELISA

status

RUO

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