Semaphorin 7A (SEMA7A) Antibody

Este producto es parte de SEMA7A - semaphorin 7A
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221€ (50 µg)

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935106861
info@markelab.com
name
Semaphorin 7A (SEMA7A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx326867
tested applications
ELISA, IHC

Description

SEMA7A Antibody is a Rabbit Polyclonal against SEMA7A.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetSemaphorin 7A (SEMA7A)
HostRabbit
ReactivityHuman, Mouse, Rat
Recommended DilutionELISA: 1/10000 - 1/20000, IHC: 1/50 - 1/300. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationPurified by affinity chromatography.
Size 150 µg
Size 2100 µg
FormLiquid
Tested ApplicationsELISA, IHC
BufferPBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDO75326
Gene ID8482
AliasJohnMiltonHagen blood group,JMH,CD108,SEMAL,CDw108,PFIC11,SEMAK1,H-Sema-L,H-SEMA-K1,JMH blood group antigen,Semaphorin-K1,Semaphorin-L
BackgroundAntibody anti-SEMA7A
StatusRUO

Descripción

Semaphorin 7A (SEMA7A) is a membrane-associated protein that belongs to the semaphorin family, a group of proteins widely recognized for their roles in axon guidance, immune response, and cellular signaling. Semaphorins, initially identified as axon-guidance molecules, are now understood to function across a variety of biological systems, impacting cell-cell interactions, cell migration, and immune cell regulation. SEMA7A, also referred to as CD108, is distinct from other semaphorins due to its glycophosphatidylinositol (GPI) anchorage, allowing it to localize on the cell surface and interact with various receptors. SEMA7A is broadly expressed in a range of tissues, including the nervous system, immune cells, skin, and certain cancer types. It is known to participate in axonal guidance, immune regulation, bone development, and pathological conditions, such as tumorigenesis and fibrotic diseases. One of its key functions is promoting axonal outgrowth and guiding neural connections, mediated through its interactions with integrins and other receptors. Furthermore, SEMA7A is actively involved in inflammatory and immune responses, modulating immune cell migration, adhesion, and activation. This diversity in function makes SEMA7A a molecule of interest in fields ranging from neurobiology to immunology and oncology.

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