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Semaphorin 3E (SEMA3E) Antibody
proveedor
Abbexareference
abx174503Tested Applications
WB, IHC, IF/ICCreactivity
Humanstatus
RUOclonality
MonoclonalDescripción
This product is currently in development. The lead time for this product may be several months. Please contact us at info@markelab.com for an updated lead time before purchasing this product. Semaphorin 3E (SEMA3E) Antibody is a Mouse Monoclonal antibody against Semaphorin 3E (SEMA3E).
Background
Semaphorins constitute a large family of cell surface and secreted guidance molecules, categorized into eight classes due to their structural variations, They show a conserved sema domain in their N-terminal region. They primarily function as short-range inhibitory signals, particularly crucial in directing axons away from inappropriate areas, especially during neural system development. Plexins are the primary receptors for semaphorins, often working alongside neuropilins as co-receptors in receptor complexes. These molecules have various roles, and some classes of semaphorins (SEMA3,SEMA4,SEMA4,SEMA6 ,SEMA7)are found in vertebrates, contributing to processes like atherosclerosis by affecting endothelial function, leukocyte infiltration, monocyte-macrophage retention, platelet hyperreactivity, and neovascularization. SEMA3E , also known by aliases like M-SEMAH, M-SemaK, SEMAH, coll-5, and semaphorin 3E, plays diverse roles in immune response, influencing processes such as cell migration, proliferation, and cytokine release through its interaction with its receptor, plexinD1
Background
Las semaforinas constituyen una gran familia de moléculas guía secretadas y de superficie celular, clasificadas en ocho clases debido a sus variaciones estructurales. Muestran un dominio sema conservado en su región N-terminal. Funcionan principalmente como señales inhibidoras de corto alcance, particularmente cruciales para alejar los axones de áreas inapropiadas, especialmente durante el desarrollo del sistema neuronal. Las plexinas son los receptores principales de las semaforinas y a menudo trabajan junto con las neuropilinas como correceptores en complejos receptores. Estas moléculas tienen varias funciones y algunas clases de semaforinas (SEMA3, SEMA4, SEMA4, SEMA6, SEMA7) se encuentran en los vertebrados y contribuyen a procesos como la aterosclerosis al afectar la función endotelial, la infiltración de leucocitos, la retención de monocitos y macrófagos, la hiperreactividad plaquetaria y la neovascularización. . SEMA3E, también conocido por alias como M-SEMAH, M-SemaK, SEMAH, coll-5 y semaforina 3E, desempeña diversas funciones en la respuesta inmune, influyendo en procesos como la migración celular, la proliferación y la liberación de citocinas a través de su interacción con su receptor. , plexinaD1
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Human
immunogen target
Semaphorin 3E (SEMA3E)
host
Mouse
conjugation
Unconjugated
form
Liquid
tested applications
WB, IHC, IF/ICC
purification
Purified by Protein A and Protein G affinity chromatography.
buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
size 1
1 ml
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
SEMA3E
dry ice
No
availability
Please enquire.
alias
SEMAH,coll-5,M-SEMAH,M-SemaK,Semaphorin-3E
note
This product is for research use only.
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