Semaphorin 3E (SEMA3E) Antibody
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Description
Semaphorin 3E Antibody is a Rabbit Polyclonal against Semaphorin 3E.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Semaphorin 3E (SEMA3E) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15041 |
| Alias | SEMAH,coll-5,M-SEMAH,M-SemaK,Semaphorin-3E |
| Background | Antibody anti-SEMA3E |
| Status | RUO |
Descripción
SEMA3E (Semaphorin 3E) stands out for its dual roles in cellular attraction and repulsion, depending on the receptor context. It binds to plexin D1 as its primary receptor, modulating endothelial cell migration, angiogenesis, and neuronal pathfinding. SEMA3E is unique in its receptor-independent signaling pathways, contributing to its versatile biological functions. In cancer, SEMA3E often exhibits a pro-metastatic role, facilitating tumor cell invasion and vascular remodeling. Its aberrant expression is implicated in aggressive tumor phenotypes, making it a target of interest for anticancer therapies aimed at modulating its signaling pathways.
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