Semaphorin 3A (SEMA3A) Antibody

Descripción

SEMA3A is a member of the semaphorin family with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.

Background

Semaphorins constitute a large family of cell surface and secreted guidance molecules, categorized into eight classes due to their structural variations, They show a conserved sema domain in their N-terminal region. They primarily function as short-range inhibitory signals, particularly crucial in directing axons away from inappropriate areas, especially during neural system development. Plexins are the primary receptors for semaphorins, often working alongside neuropilins as co-receptors in receptor complexes. These molecules have various roles, and some classes of semaphorins (SEMA3,SEMA4,SEMA4,SEMA6 ,SEMA7)are found in vertebrates, contributing to processes like atherosclerosis by affecting endothelial function, leukocyte infiltration, monocyte-macrophage retention, platelet hyperreactivity, and neovascularization. Semaphorin-3A, encoded by the SEMA3A gene in humans, plays essential roles in the development of the olfactory system and the regulation of puberty. It induces the collapse and paralysis of neuronal growth cones, potentially acting as a ligand to guide specific growth cones through a motility-inhibiting mechanism. Semaphorin-3A exerts its effects by binding to the neuropilin-1/plexin-1 complex

Background

Las semaforinas constituyen una gran familia de moléculas guía secretadas y de superficie celular, clasificadas en ocho clases debido a sus variaciones estructurales. Muestran un dominio sema conservado en su región N-terminal. Funcionan principalmente como señales inhibidoras de corto alcance, particularmente cruciales para alejar los axones de áreas inapropiadas, especialmente durante el desarrollo del sistema neuronal. Las plexinas son los receptores principales de las semaforinas y a menudo trabajan junto con las neuropilinas como correceptores en complejos receptores. Estas moléculas tienen varias funciones y algunas clases de semaforinas (SEMA3, SEMA4, SEMA4, SEMA6, SEMA7) se encuentran en los vertebrados y contribuyen a procesos como la aterosclerosis al afectar la función endotelial, la infiltración de leucocitos, la retención de monocitos y macrófagos, la hiperreactividad plaquetaria y la neovascularización. . La semaforina-3A, codificada por el gen SEMA3A en humanos, desempeña funciones esenciales en el desarrollo del sistema olfativo y la regulación de la pubertad. Induce el colapso y la parálisis de los conos de crecimiento neuronal, actuando potencialmente como un ligando para guiar conos de crecimiento específicos a través de un mecanismo inhibidor de la motilidad. La semaforina-3A ejerce sus efectos uniéndose al complejo neuropilina-1/plexina-1

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

Semaphorin 3A (SEMA3A)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB, IHC

purification

Purified Rabbit Polyclonal Antibody.

buffer

PBS containing 0.09% sodium azide.

size 1

80 µl

size 2

400 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

SEMA3A

dry ice

availability

Shipped within 5-10 working days.

alias

HH16,SemD,COLL1,SEMA1,SEMAD,SEMAL,coll-1,Hsema-I,SEMAIII,Hsema-III,Semaphorin III,Semaphorin-3A

uniprot id

https://www.uniprot.org/uniprotkb/Q14563

note

This product is for research use only.

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