Semaphorin 3A (SEMA3A) Antibody
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935106861
info@markelab.com
Precio
281.25€ (80 µl)
Antibody anti-SEMA3A
proveedor
Abbexareference
abx033665Tested Applications
ELISA, WB, IHCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
SEMA3A is a member of the semaphorin family with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.
Background
SEMA3A (Semaphorin 3A) is a member of the class 3 semaphorin family, functioning as a guidance cue in axonal development and neuronal migration. It binds to neuropilin-1 (NRP1) and plexin receptors to mediate repulsive signaling in neural networks, playing a critical role in synapse formation and maintenance. Beyond neural contexts, SEMA3A also influences angiogenesis, immune cell regulation, and cancer progression, with high relevance in tumor microenvironments where it modulates vascular growth and cell invasion. Its therapeutic potential lies in targeting its pathways for diseases involving aberrant cell migration and angiogenesis, including cancer and vascular disorders.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Semaphorin 3A (SEMA3A)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purification
Purified Rabbit Polyclonal Antibody.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
SEMA3A
dry ice
No
availability
Shipped within 5-10 working days.
alias
HH16,SemD,COLL1,SEMA1,SEMAD,SEMAL,coll-1,Hsema-I,SEMAIII,Hsema-III,Semaphorin III,Semaphorin-3A
uniprot id
note
This product is for research use only.
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