Second Mitochondria-Derived Activator of Caspase / SMAC (DIABLO) Antibody
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Description
Second Mitochondria-Derived Activator of Caspase / SMAC (DIABLO) Antibody is a Mouse Monoclonal antibody against Second Mitochondria-Derived Activator of Caspase / SMAC (DIABLO).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Second Mitochondria-Derived Activator of Caspase / SMAC (DIABLO) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 100 µg |
| Form | Liquid |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Background | Antibody anti-DIABLO |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
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Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins(IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.This antibody recognizes all the three isoforms of DIABLO.
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